Pepsin can contribute to the pathology of a number of conditions, such as gastro-oesophageal reflux disease (GORD) and laryngopharyngeal reflux (LPR).

Peptest is a highly accurate, non-invasive diagnostic test for detecting pepsin in saliva, sputum, and other clinical samples. It is often used with people who remain symptomatic after taking acid-suppressing medication, or who have atypical ear, nose and throat symptoms of GORD.

When you have collected your saliva samples, following the instructions, you then need to send them to our laboratory for testing.

In the lab, we use specialist equipment to process your samples before testing them on the Peptest device itself. After 15 minutes the test line of the Peptest device is scanned with an electronic reader to give a quantitative result or in layman’s terms the amount of pepsin present in your sample. This concentration of pepsin can give your clinician important pointers to the severity of your reflux events.

How do I get my Peptest results?

You will receive a report indicating whether each sample is positive or negative. If positive you will be given a reading of the concentration of pepsin in the sample.

Depending on your symptoms and the results of your Peptest analysis, the next step would be to share and discuss your results with your GP/Doctor.

If your results are positive, along with your results report you will also receive a GP letter, which explains more about Peptest and your results.

As we record your pepsin levels it can provide a benchmark to measure against future testing. In this way, you can assess the effectiveness of treatments, lifestyle advice or even surgery by looking at the new level of pepsin after the intervention.

Peptest Results

Customer case studies

Garry suffered from persistent breathing problems alongside other symptoms, including cough, throat clearing, chest pain and post nasal drip. His Peptest results showed high levels of pepsin present in his saliva. He shared the results with his doctor and discussed the treatment he needed. At first, he was prescribed a proton pump inhibitor (PPI) to lower the acidity in the stomach. However, after suffering from reflux for almost two years, Garry decided to undergo LINX surgery. Six weeks after Garry’s LINX surgery he used Peptest again to test for pepsin in his airways and his results showed his saliva negative for the enzyme.

Muriela suffered from continual coughing – particularly at night – for 12 years. Peptest confirmed high levels of pepsin in her saliva, as well as the levels involved and when it was happening. With this information, she worked with her GP and now takes Gaviscon Advance before going to bed. She also raises the upper body before going to sleep and waits until three hours after eating or consuming liquid.

Ian started wheezing at night and often woke up due to his heavy breathing. His Peptest results showed high levels of pepsin, especially after midday and evening meals. He took the results to his doctor, along with a recommendation that he be prescribed Gaviscon Advance. Within the space of a few weeks of taking the prescription, his symptoms stopped.