Can reflux cause polyps on vocal cords? A new study has used Peptest to explore the relationship between gastro-oesophageal reflux disease (GORD/ GERD) and vocal fold polyps.

Vocal fold polyps (VFPs) are growths that form on the vocal folds – also known as the vocal cords. These are two bands of smooth muscle tissue found in the larynx (voice box).

When the lungs force air out through the vocal cords, the two folds of tissue vibrate to produce noise. VFPs are, therefore, a common cause of hoarseness of voice.

Previous studies have suggested an association between the reflux of pepsin and the formation of vocal fold polyps. Now this new study, published in Medicine – the open access peer-reviewed medical journal – has delved into the role of pepsin in the development of VFPs.

Using Peptest, researchers at the Second Affiliated Hospital of Chongqing Medical University in China found that patients with VFPs had a significantly higher incidence of GERD as well as higher saliva pepsin concentrations and pepsin-positive rates.

The study findings suggest pepsin may promote the aggregation of immune cells, increase the local cytokines (proteins that acts as a signalling molecules), and promote inflammatory reaction.

The study also concluded that the Peptest salivary pepsin test can be a reliable alternative to pepsin immunohistochemistry (IHC) staining for the diagnosis of extraoesophageal reflux.

Download and read the study here.

An early and objective diagnosis of reflux, such as Peptest provides, opens the door to lifestyle changes, and future treatment. Peptest can also be used after reflux treatments to assess the success or failure of any treatment. Find out more about Peptest and order your Peptest home testing kit now.
Disclaimer: This is an informational blog. You can always get in touch if you have any questions.

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