Peptest has been used to evaluate the success of laparoscopic fundoplication surgery for the treatment of reflux disease in a new research study.

Laparoscopic fundoplication surgery is when the top part of the stomach is wrapped around the lower part of the oesophagus to create a new valve that stops stomach contents from refluxing.

Twenty adults who underwent laparoscopic fundoplication at the Surgical Department of the Sisters of Charity Hospital in Austria between October 2014 and May 2016 due to chronic GERD with primary extra-oesophageal symptoms were included in the study.

Extra-oesophageal symptoms include cough, hoarseness, frequent throat clearing, throat discomfort, or asthma-like symptoms alone or in addition to heartburn and regurgitation.

Researchers evaluated the value of pepsin concentration in the saliva and pharyngeal pH-monitoring as tests to predict surgical outcome of patient’s laryngopharyngeal reflux (LPR).

All patients underwent a baseline pathological ENT examination and a preoperative series of diagnostic tests including the measurement of the concentration of salivary pepsin. The evaluation of salivary pepsin was analysed using Peptest.
In post-surgery follow-ups, comprising repeat diagnostic tests and the repeat measurement of salivary pepsin using Peptest, a 63 per cent reduction in the concentration of pepsin was observed.

Professor Peter Dettmar explains the findings: “This significant reduction in pepsin concentration in the saliva of postoperative patients represented a marker of treatment success and further evidence that pepsin plays a role in the pathophysiology of LPR.”

“This well-designed study suggests that Peptest could be used as a part of the post-operative follow-up procedure for laparoscopic fundoplication (and potentially other surgical methods) as a simple measure of the success in reducing the severity of reflux events.”

Download research paper “Role of Pepsin and Oropharyngeal pH-Monitoring to Assess the Postoperative Outcome of Patients with Laryngopharyngeal Reflux: Results of a Pilot Trial”